[HTML][HTML] Monoclonal anti‑MUC1 antibody with novel octahydropyrazino [2, 1‑a: 5, 4‑a'] diisoquinoline derivative as a potential multi‑targeted strategy in MCF‑7 breast …
A Gornowicz, W Szymanowski… - Oncology …, 2019 - spandidos-publications.com
… that the new diisoquinoline derivatives could modulate both … novel octahydropyrazin[2,1-a:5,4-a′]diisoquinoline
derivative (OM… Anticancer agents can be designed to target specific cell …
derivative (OM… Anticancer agents can be designed to target specific cell …
[HTML][HTML] The anticancer action of a novel 1, 2, 4-triazine sulfonamide derivative in colon cancer cells
A Gornowicz, A Szymanowska, M Mojzych… - Molecules, 2021 - mdpi.com
… two or three chemotherapeutic agents paired with biologics such as anti-VEGF agents or
anti-EGFR drugs… and a novel octahydropyrazino[2,1-a:5,4-a′]diisoquinoline derivative (OM-86II…
anti-EGFR drugs… and a novel octahydropyrazino[2,1-a:5,4-a′]diisoquinoline derivative (OM-86II…
[HTML][HTML] Mucin 1 as a molecular target of a novel diisoquinoline derivative combined with anti-MUC1 antibody in AGS gastric cancer cells
A Gornowicz, W Szymanowski, K Bielawski, Z Kałuża… - Molecules, 2021 - mdpi.com
… with the novel diisoquinoline derivative caused a decrease in … and 48 h of incubation,
respectively (Figure 4A,B). Taking into … that the combination of the chemotherapeutic agent with …
respectively (Figure 4A,B). Taking into … that the combination of the chemotherapeutic agent with …
[HTML][HTML] The Effect of Novel 7-methyl-5-phenyl-pyrazolo[4,3-e]tetrazolo[4,5-b][1,2,4]triazine Sulfonamide Derivatives on Apoptosis and Autophagy in DLD-1 and HT …
A Gornowicz, A Szymanowska, M Mojzych… - International Journal of …, 2020 - mdpi.com
… novel approaches and new chemotherapeutic agents. Other … new biologically active molecules,
including anticancer activity… range of biological activities. Many mono and condensed 1,…
including anticancer activity… range of biological activities. Many mono and condensed 1,…
[HTML][HTML] Discovering simple phenylboronic acid and benzoxaborole derivatives for experimental oncology–phase cycle-specific inducers of apoptosis in A2780 …
M Psurski, A Łupicka-Słowik… - … new drugs, 2019 - Springer
… as a novel class of potential anticancer agents. … assessment at various time points indicated
that prolonged treatment was necessary to reveal the high antiproliferative potential (Fig. 4a). …
that prolonged treatment was necessary to reveal the high antiproliferative potential (Fig. 4a). …
[HTML][HTML] Pyrazole derivatives induce apoptosis via ROS generation in the triple negative breast cancer cells, MDA-MB-468
M Ashourpour, F Mostafavi-Hosseini… - Asian Pacific Journal …, 2021 - ncbi.nlm.nih.gov
… In an effort to introduce a new anticancer agent for bladder cancer, a series of pyrazoline
derivatives was utilized on 5647 and T24 cells as two human bladder cancer cell line. The …
derivatives was utilized on 5647 and T24 cells as two human bladder cancer cell line. The …
[HTML][HTML] Autophagy modulators in cancer therapy
K Buzun, A Gornowicz, R Lesyk, K Bielawski… - International Journal of …, 2021 - mdpi.com
… However, intentional inhibition of adaptive autophagy leads to reversal of this phenomenon,
causing cells re-sensitization to ionizing radiation or used chemotherapeutic agents [128,…
causing cells re-sensitization to ionizing radiation or used chemotherapeutic agents [128,…
Tanshinone IIA shows higher antiproliferative activities than Sinapic acid in 4 cancer cell lines and simultaneously induces apoptosis and necroptosis in human lung …
CY Lin, M Tam Ly, SH Yang, SC Lai… - Natural Product …, 2021 - journals.sagepub.com
… Indeed, advanced lung cancer is frequently resistant to apoptosis-based anticancer drugs,
and A549 cells are usually selected as a model to evaluate drug resistance. Tan IIA shows …
and A549 cells are usually selected as a model to evaluate drug resistance. Tan IIA shows …
Comparison of methods for the quantification of cell-free DNA isolated from cell culture supernatant
AJ Bronkhorst, V Ungerer, S Holdenrieder - Tumor Biology, 2019 - journals.sagepub.com
… (n = 2), and NanoDrop One c (n = 2). Each bar indicates the average concentration of cfDNA
measured in two biological replicates (ie two cell culture flasks) and two isolation replicates. …
measured in two biological replicates (ie two cell culture flasks) and two isolation replicates. …